Blog

Jeffrey I. Greenstein, M.D.
President, MSRI

August 20, 2018

Dear Friend and Supporter

I am pleased to share with you some of the groundbreaking discoveries made at MSRI over the last few months due to your generous support.

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2018 May 30. doi: 10.1089/rej.2017.2049

Abstract

Proteostasis, which includes the repair and disposal of misfolded proteins, depends, in part, on the activity of heat shock proteins (HSPs), a well-known class of chaperone molecules. When this process fails, abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases, but also amass during aging, often in the absence of an identified clinical disorder.

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Featured Post

Since MSRI’s inception, Dr. Greenstein has completed the renovation of the MSRI laboratory and has made significant progress in identifying the cause of MS as well as developing a potential treatment. MSRI needs your help to take Dr. Greenstein’s research to the next level. Please consider purchasing an engraved tile to be placed in the MSRI Laboratory. The tile may honor a loved one, friend or the many lives affected by this disabling disease. Help MSRI FIND the cause, STOP the progression, and CURE MS.

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We have worked on the JC virus for many months to understand how this virus travels to the brain causing PML (Progressive Multifocal Leukoencephalopathy) a serious and potentially fatal infection which complicates a number of MS therapies including Tysabri, Tecfidera, Gilenya, Ocrevus and Lemtrada. This infection also complicates treatments for other autoimmune diseases, transplantation and chemotherapy; and is seen in different immune deficiencies and HIV-AIDS. There are at least 15 monoclonal antibody treatments for different conditions which are complicated by the JC virus.

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Jeffrey I. Greenstein, M.D.
President, MSRI

November 2, 2017

Dear Friend and Supporter,

I am pleased to give you an update on one of our research projects.

We have worked on the JC virus for many months to understand how this virus travels to the brain causing PML (Progressive Multifocal Leukoencephalopathy) a serious and potentially fatal infection which complicates a number of MS therapies including Tysabri, Tecfidera, Gilenya, Ocrevus and Lemtrada. This infection also complicates treatments for other autoimmune diseases, transplantation and chemotherapy; and is seen in different immune deficiencies and HIV-AIDS. There are at least 15 monoclonal antibody treatments for different conditions which are complicated by the JC virus.

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Jeffrey I. Greenstein, M.D.
President, MSRI

December 8, 2016

Dear Friend and Supporter,

As we approach the end of the year, I would like to give you an update on our research efforts at MSRI.

Dr. Yuenmu Chen joined us in September, bringing with him a wealth of experience in Molecular Biology and Molecular Pharmacology. He has already made a major contribution to our capacity to perform experiments using both his expertise and technical ability. I look forward to a long-term working relationship to FIND, STOP, and CURE MS.

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“Sorry for the delay,” said Dr. Jeffrey Greenstein in a smooth, lightly accented baritone, when he came to the phone after a few minutes. “We just got so engrossed in a problem in the lab, I totally forgot the time.”

Losing track of time in the lab is probably not an unfamiliar experience for Greenstein, who has devoted his professional life to treating and researching multiple sclerosis and remains as passionately interested in it now as he was as a medical student in his native South Africa.

“MS is the prime disabling neurologic condition of young adults,” Greenstein said in explaining why he’s devoted his life to ultimately finding a cure for the disease, which affects as many as 2.5 million people worldwide. “More than any other disease, this is a disease that disables people in their productive years.”

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FIND, STOP, CURE MS