Jeffrey I. Greenstein, M.D.
November 2, 2017
Dear Friend and Supporter,
I am pleased to give you an update on one of our research projects.
We have worked on the JC virus for many months to understand how this virus travels to the brain causing PML (Progressive Multifocal Leukoencephalopathy) a serious and potentially fatal infection which complicates a number of MS therapies including Tysabri, Tecfidera, Gilenya, Ocrevus and Lemtrada. This infection also complicates treatments for other autoimmune diseases, transplantation and chemotherapy; and is seen in different immune deficiencies and HIV-AIDS. There are at least 15 monoclonal antibody treatments for different conditions which are complicated by the JC virus.