Regulatory B cells or bregs, as Harrisburg, PA scientists have proven, play various roles in the immune response and the creation of antibodies against various diseases. Different mechanisms are used by bregs, Harrisburg, PA researchers say, in regulating the immune system. The involvement of bregs, Harrisburg, PA studies show, can be found in diseases like multiple sclerosis, inflammation, and tumor.
Roles of Bregs In Harrisburg, PA Patients’ Medical Conditions
Understanding the role of bregs among Harrisburg, PA patients can help give light to the processes that occur when they suppress the immune responses to protect the body from virus or infection. Findings from studies on bregs, Harrisburg, PA experts say, help in making necessary alterations when treating various medical conditions and making changes in transplantation procedures.
Here are some of the roles of bregs in Harrisburg, PA patients’ conditions. Read on to discover the functions that Regulatory B cells take to ensure the body is protected from antigens and other foreign substances.
Autoimmune Diseases
Bregs, Harrisburg, PA researchers reveal, have an inverse relationship with autoimmune diseases. The lower number and weaker function of bregs, Harrisburg, PA specialists say, implies the severity of medical conditions. Bregs among Harrisburg, PA patients help protect the body from the dire effects of multiple sclerosis, lupus, rheumatoid arthritis, diabetes, and bowel diseases.
Allergies
Chronic inflammation is present during allergic reactions. Thanks to bregs, Harrisburg, PA patients with allergic diseases can experience fewer symptoms. Bregs, Harrisburg, PA physicians proved, are involved in bringing about and maintaining allergen tolerance. Because of these findings, bregs, Harrisburg, PA biologists say, are potential tools in the development of targeted therapies.
Cancer
Recent studies reveal that bregs among Harrisburg, PA patients help in suppressing the immune response to cancer. Bregs, Harrisburg, PA researchers pointed out, can facilitate tumor progression. These discoveries helped in utilizing Regulatory B cells by recruiting them into the tumor with their immunosuppressive properties.
Infections
Bregs, Harrisburg, PA research posits, also plays a role in various infectious diseases involving salmonella, hepatitis b virus, and malaria. Bregs, Harrisburg PA studies show, are induced in these conditions. Bregs in Harrisburg, PA experimental subjects have protective immunity against infections.
Bregs, Harrisburg, PA biologists can confirm, are naturally responsible for antibody production. But they’re also assumed to prevent the inflammatory responses from worsening. Hence, Malaria’s negative impact on one’s health can be regulated thanks to bregs, Harrisburg, PA researchers say.
Transplantation
Recent studies reveal that bregs among Harrisburg, PA patients play a role during transplantation. For one, bregs in Harrisburg, PA have suppressive properties that provide a cushion or protective layer to the immune response. Bregs, Harrisburg, PA researchers say, allow for transplant tolerance.
Bregs among Harrisburg, PA patients also help in graft rejection. This ensures the transplanted tissue or organ will not be destroyed. These findings are being considered in making minimal changes in transplantation ad recovery therapies.
Pregnancy
Bregs, Harrisburg, PA researchers claim, are involved in making sure there is immune tolerance in the womb throughout pregnancy. Thanks to bregs, Harrisburg, PA biologists say, the inflammatory responses are reduced and replaced by antibody responses.
When babies are born, Regulatory B cells contribute to decreasing the risk of developing infections. Although newborns have the ability to fight disease-causing organisms, bregs are partly responsible for making sure the body prevents excessive responses to antigens.
What We Do at Multiple Sclerosis Research Institute
We are a nonprofit foundation whose goal is to cure and stop various immunological diseases including multiple sclerosis. For us to achieve it, we conduct laboratory and translational research so we can come up with innovative treatments. Our mission can help advance health care and provide an outstanding education for those affected by MS.
Multiple Sclerosis Research Institute seeks volunteers and financial support from able organizations and individuals. Help us make a change in the lives of those affected by MS. Get in touch with our staff for questions and concerns.
Multiple Sclerosis Research Institute
Our non-profit foundation was started by Dr. Jeffrey Greenstein to Find, Stop and Cure MS. We focus on:
Conducting basic laboratory research into the cause and development of MS.
Developing translational research – moving from the laboratory to clinical applications – to foster new and innovative MS treatments.
Providing MS education for the public, including patients, caregivers, health care professionals, and MS specialists.
With our newly created laboratory and the hiring of proper research personnel, we have been experiencing an exciting season of development and growth. Right now is the perfect time for us to push for new studies and discoveries with support from the public.
Our Research
Multiple Sclerosis Research Institute is committed to conducting the highest quality laboratory-based research. The following are just some of our publications:
- Greenstein JI: Diffuse dermatophytosis occurring on dimethyl fumarate therapy Multiple Sclerosis Journal 2018:24(7) 999-1001
- Editorial comment on the paper: Correale J: New fungal infections associated with disease-modifying treatments in MS Multiple Sclerosis Journal 2018: 24(7) 1004-1006.
- Cunningham TJ, Greenstein JI, Yao L, Fischer I, Connors T. Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
- Cunningham, TJ, Oetinger, M, Blankenhorn EP, Greenstein, JI. Secreted Phospholipase A2 activity in experimental allergic encephalomyelitis and multiple sclerosis. Journal of Neuroinflammation 2006; 3:26
- Greenstein JI. Current concepts of the cellular and molecular pathophysiology of Multiple Sclerosis. Developmental Neurobiology 2008; 67:1248-1265.
- Cunningham, TJ, Greenstein, JI et al. Uncompetitive Phospholipase A2 inhibition by CHEC sequences including oral treatment of experimental autoimmune myeloencephalitis. The Open Enzyme Inhibition Journal 2009; 2:1-7.
- Greenstein JI, Cunningham TJ. Neuroprotective, Anti-inflammatory and Immune Tolerizing properties of peptides derived from Diffusion Survival Evasion Protein (DSEP)/Dermcidin. Academy of Neurology Annual Meeting April, 2014.
- Cunningham TJ, Greenstein JI, Loewenstein J, Degermentzidis. Anti-inflammatory peptide regulates supply of heat shock protein 70 monomers: Implications for aging and aging-related disease. Rejuvenation Research. 2015. 18(2):136-144.
- Buckle G, Bandari BD, Greenstein JI, et al. Effect of delayed-release Dimethyl Fumarate on lymphocyte subsets in patients with Relapsing Multiple Sclerosis: Interim analysis of REALIZE. Consortium of Multiple Sclerosis Centers. 2016 Annual Meeting.
Get Involved
If you’re also a firm believer of what we do here at Multiple Sclerosis Research Institute, there are several ways for you to get involved and help. Here are some of them:
- Volunteer
We’re seeking volunteers who will work to promote our well-defined mission to supporting entities. Anyone interested is welcome to submit a volunteer form through our website.
- Donate
As a fully incorporated 501(c)(3) non-profit foundation, the MSRI gets funding from individuals, corporations, foundations, and other organizations to continue what we do. Funding is crucial to ensure appropriate facilities and staffing for significant MS research. Without donations, we cannot continue our research and other programs.
Tax-deductible contributions are much appreciated. Checks made payable to “Multiple Sclerosis Research Institute” can be mailed to our address. You may also opt to contribute stock; contact us for the transfer information. For donations that will be made through credit card, PayPal, or GoFundMe, kindly visit our donation page for our links. We value any amount.
- Amazon Smile
Shop and help. For Amazon shoppers out there, we’re part of the charitable organizations under the AmazonSmile Foundation program. Pick us, Multiple Sclerosis Research Institute (“MSRI”), as your charity of choice the next time you check out your cart from smile.amazon.com.
- Buy From Our Shop
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Contact Us
Get in touch with Multiple Sclerosis Research Institute today for more information about us, what we do, and what we can do for you. You may also contact us if you would like to donate or volunteer. Anyone looking to learn more about multiple sclerosis is also welcome to reach out to us. We look forward to hearing from you soon.
Multiple Sclerosis Research Institute
Penn Treaty Park Place
1341 N. Delaware Ave Suite 213
Philadelphia PA 19125
Office — (267) 687-7027
Fax — (267) 687-7466
Email: info@msresearchinstitute.org