If you’re ever wondering how the immune system can differentiate your cells from foreign ones, there is a mechanism in your body responsible for that. It’s called MHC (Major Histocompatibility Complex) in Harrisburg, PA. To understand how it protects you from invading pathogens, you need an in-depth explanation of their functions. Read further to learn more about MHC (Major Histocompatibility Complex) in Harrisburg, PA.
What Is MHC (Major Histocompatibility Complex) in Harrisburg, PA
MHC (Major Histocompatibility Complex) in Harrisburg, PA, is a collection of glycoproteins or proteins with a carbohydrate located on a healthy cell’s surface. Our immune system is able to identify non-self cells by the anomaly in the MHC (Major Histocompatibility Complex) in Harrisburg, PA displayed on the plasma membrane.
There are two groups of molecules under MHC (Major Histocompatibility Complex) in Harrisburg, PA that generates different markings on a cell’s surface. The first class of MHC (Major Histocompatibility Complex) in Harrisburg, PA present endogenous antigens, or antigens made inside the cells as either self or non-self pathogens.
The second class of MHC (Major Histocompatibility Complex) in Harrisburg, PA are produced by APCs (Antigen-Presenting Cells) like macrophages and B cells. They ingest and break down antigens that originate outside the cell before combining with MHC (Major Histocompatibility Complex) in Harrisburg, PA. From there, they present as non-self pathogens to be recognized by T cells.
Functions of MHC (Major Histocompatibility Complex) in Harrisburg, PA
The main role of MHC (Major Histocompatibility Complex) in Harrisburg, PA is antigen presentation. Its molecules display peptide fragments of the cytoplasmic membrane of the cell to be recognized by killer T-cells. MHC (Major Histocompatibility Complex) in Harrisburg, PA is important to prevent the immune system from attacking its own cells.
Certain alleles of MHC (Major Histocompatibility Complex) in Harrisburg, PA are contributors of genetic susceptibility to autoimmune diseases like multiple sclerosis, Hodgkin’s lymphoma, and Crohn’s disease. Another function of MHC (Major Histocompatibility Complex) in Harrisburg, PA is tissue allorecognition, which is a factor heavily considered during organ transplants.
MHC (Major Histocompatibility Complex) in Harrisburg, PA and Antigen Representation
The MHC (Major Histocompatibility Complex) in Harrisburg, PA is responsible for controlling how the immune system detects and responds to certain antigens. T cell recognition largely depends on the different antigen presentation between the two molecule classes of MHC (Major Histocompatibility Complex) in Harrisburg, PA. However, they both involve the delivery of short peptides to the cytoplasmic membrane.
MHC (Major Histocompatibility Complex) in Harrisburg, PA and Autoimmunity
There are certain molecules under MHC (Major Histocompatibility Complex) in Harrisburg, PA associated with increased risk of autoimmune diseases. Disease associations of MHC (Major Histocompatibility Complex) in Harrisburg, PA found that there is a disease susceptibility to alleles that surface from HLA-DRY haplotypes, suggesting the disease-specific correlation between MHC and autoimmunity.
MHC (Major Histocompatibility Complex) in Harrisburg, PA and Tissue Allorecognition
During organ transplants, there is a chance that an individual’s body will reject the tissue transplanted to them. MHC (Major Histocompatibility Complex) in Harrisburg, PA is involved in the mechanism where T cells recognize the donor’s determinants through molecule-peptide complex displayed on the cell surface. The molecules of MHC (Major Histocompatibility Complex) in Harrisburg, PA present an antigenic determinant which will be recognized as non-self.
Learn More About MHC (Major Histocompatibility Complex) in Harrisburg, PA
At Multiple Sclerosis Research Institute, we focus on conducting laboratory research to find more information in the field of Multiple Sclerosis (MS). We look into possible causes and development of the disease such as the association of MHC (Major Histocompatibility Complex) in Harrisburg, PA in increasing the risk of MS
With your help, we can further our study on MHC (Major Histocompatibility Complex) in Harrisburg, PA and possibly foster innovative MS treatments in the future. We have been experiencing growth with a newly created laboratory and hiring quite a number of research personnel. Our institute seeks funding from individuals, corporations, foundations, and other organizations. Contact us today if you’re interested in supporting our mission.
Multiple Sclerosis Research Institute
Our non-profit foundation was started by Dr. Jeffrey Greenstein to Find, Stop and Cure MS. We focus on:
Conducting basic laboratory research into the cause and development of MS.
Developing translational research – moving from the laboratory to clinical applications – to foster new and innovative MS treatments.
Providing MS education for the public, including patients, caregivers, health care professionals, and MS specialists.
With our newly created laboratory and the hiring of proper research personnel, we have been experiencing an exciting season of development and growth. Right now is the perfect time for us to push for new studies and discoveries with support from the public.
Our Research
Multiple Sclerosis Research Institute is committed to conducting the highest quality laboratory-based research. The following are just some of our publications:
- Greenstein JI: Diffuse dermatophytosis occurring on dimethyl fumarate therapy Multiple Sclerosis Journal 2018:24(7) 999-1001
- Editorial comment on the paper: Correale J: New fungal infections associated with disease-modifying treatments in MS Multiple Sclerosis Journal 2018: 24(7) 1004-1006.
- Cunningham TJ, Greenstein JI, Yao L, Fischer I, Connors T. Heptamer Peptide Disassembles Native Amyloid in Human Plasma Through Heat Shock Protein 70.
- Cunningham, TJ, Oetinger, M, Blankenhorn EP, Greenstein, JI. Secreted Phospholipase A2 activity in experimental allergic encephalomyelitis and multiple sclerosis. Journal of Neuroinflammation 2006; 3:26
- Greenstein JI. Current concepts of the cellular and molecular pathophysiology of Multiple Sclerosis. Developmental Neurobiology 2008; 67:1248-1265.
- Cunningham, TJ, Greenstein, JI et al. Uncompetitive Phospholipase A2 inhibition by CHEC sequences including oral treatment of experimental autoimmune myeloencephalitis. The Open Enzyme Inhibition Journal 2009; 2:1-7.
- Greenstein JI, Cunningham TJ. Neuroprotective, Anti-inflammatory and Immune Tolerizing properties of peptides derived from Diffusion Survival Evasion Protein (DSEP)/Dermcidin. Academy of Neurology Annual Meeting April, 2014.
- Cunningham TJ, Greenstein JI, Loewenstein J, Degermentzidis. Anti-inflammatory peptide regulates supply of heat shock protein 70 monomers: Implications for aging and aging-related disease. Rejuvenation Research. 2015. 18(2):136-144.
- Buckle G, Bandari BD, Greenstein JI, et al. Effect of delayed-release Dimethyl Fumarate on lymphocyte subsets in patients with Relapsing Multiple Sclerosis: Interim analysis of REALIZE. Consortium of Multiple Sclerosis Centers. 2016 Annual Meeting.
Get Involved
If you’re also a firm believer of what we do here at Multiple Sclerosis Research Institute, there are several ways for you to get involved and help. Here are some of them:
- Volunteer
We’re seeking volunteers who will work to promote our well-defined mission to supporting entities. Anyone interested is welcome to submit a volunteer form through our website.
- Donate
As a fully incorporated 501(c)(3) non-profit foundation, the MSRI gets funding from individuals, corporations, foundations, and other organizations to continue what we do. Funding is crucial to ensure appropriate facilities and staffing for significant MS research. Without donations, we cannot continue our research and other programs.
Tax-deductible contributions are much appreciated. Checks made payable to “Multiple Sclerosis Research Institute” can be mailed to our address. You may also opt to contribute stock; contact us for the transfer information. For donations that will be made through credit card, PayPal, or GoFundMe, kindly visit our donation page for our links. We value any amount.
- Amazon Smile
Shop and help. For Amazon shoppers out there, we’re part of the charitable organizations under the AmazonSmile Foundation program. Pick us, Multiple Sclerosis Research Institute (“MSRI”), as your charity of choice the next time you check out your cart from smile.amazon.com.
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Contact Us
Get in touch with Multiple Sclerosis Research Institute today for more information about us, what we do, and what we can do for you. You may also contact us if you would like to donate or volunteer. Anyone looking to learn more about multiple sclerosis is also welcome to reach out to us. We look forward to hearing from you soon.
Multiple Sclerosis Research Institute
Penn Treaty Park Place
1341 N. Delaware Ave Suite 213
Philadelphia PA 19125
Office — (267) 687-7027
Fax — (267) 687-7466
Email: info@msresearchinstitute.org